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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
27 (1): 1-9, 2023.
Differential gene expression for brain cancer by CGAP microarray
Ravichandran S, Jeyakumar N
Data Mining and Text Mining Laboratory, Department of Bioinformatics, Bharathiar University, Coimbatore 641 046, INDIA.
Ravichandran S, Jeyakumar N, Brain tumor biomarker identification by differential gene expression analysis microarray data, Onl J Vet Res., 27 (1): 1-9, 2023. We undertook a meta-analysis to identify drug brain tumor therapeutic targets over-expressed in cancer tissue compared to normal brain tissue. Data mining for differential gene expression analysis of normal and brain cancer tissue by applying sequence odds ratio for significance (P < 0.001). Analyses yielded 2298 up regulated genes in brain tumor tissues and functional annotation through gene ontology database and found 5 enriched GO categories. Analysis of Transcription Factor Activity included 75 genes in KEGG pathway database for 5 genes TCF7L1, RXRA, RXRG, RB1, and NFATC3 implicated in cancer pathways. These genes may be considered as biomarkers for brain tumors.
Keywords: Brain tumor, Differential gene expression, CGAP, DGED, Biomarkers.