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OJVRTM
Online
Journal of Veterinary Research©
24(7): 407-412, 2020.
In silico docking of endophytic
fungi cytoglobolosins to bovine coronavirus 3Cl4 receptor.
VN Sai Bindu Madhavi Patiballa, Ramya Bandarupalli, Anjani Gayatri Vegesena,
Rupa Sree Devi Vemuri, Kanaka Durga Devi Nelluri*
KVSR
Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh,
India. *Corresponding author
ABSTRACT
Madhavi Patiballa VN, Bandarupalli R, Vegesena AG, Devi
Vemuri RS, Devi Nelluri
KD., In silico docking endophytic fungi cytoglobolosins to bovine coronavirus 3Cl4 receptor, Onl J Vet Res., 24(7): 407-412, 2020. Bovine
coronavirus infects upper and lower intestine and respiratory tracts in cattle inducing
diarrhea and respiratory infections. One hundred secondary metabolites of
marine endophytic fungi protein crystal structure were screened for In silico docking with bovine coronavirus
hemagglutinin-esterase 3Cl4 receptor. We found that cytoglobosins
D (8.3Kcal/mol) CID: 46209919
and C (8.2Kcal/mol) had best binding affinity to bovine
coronavirus hemagglutinin-esterase 3Cl4 receptor compared with standard Darunavir (-6.6 Kcal/mmol). In vitro and in vivo tests may support therapeutic use for endophytic fungi CID: 46209919
against bovine coronavirus.
Key-words: In
silico, protein binding, bovine coronavirus, hemagglutinin-esterase endophytic fungi, cytoglobosins,
Darunavir.
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