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OJVRTM
Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28 (10): 758-763, 2024.
Effect of osteomorphogenic protein on healing of equine metatarsus:
Dehghani S, Aliabadi
A.
Department of Surgery, School of
Veterinary Medicine, University of Shiraz, Shiraz, Department of Veterinary Clinical Studies, Kazeroun Azad University, Kazeroun
, Iran.
ABSTRACT
Dehghani S, Aliabadi A., Effect of
osteomorphogenic protein on healing of equine
metatarsus, Onl J Vet Res., 28 (10): 758-763, 2024. Five 4.0±0.7 year, adult horses for future slaughter
were anaesthetized with 1.1mg/kg 2% Xylazine, 2mg/kg,
10% Ketamine and 0.5mg/kg Diazepam maintained by 2.5% halothane. Osteo-morphogenic protein was excised from bovine diaphyseal bone ground into 1mm particles. In horses bone
defect 30 long, 20 wide and 10mm deep was created by osteotome
on mid-shaft of right metatarsal bone was replaced with 300mg liquid suspension
of bone morphogenic protein. Five controls were replaced
by saline. In treated horses, external calluses appeared by 21 days, 42 days bridged
and 84 days was solid bone, whereas in controls, callus appeared by 42 days but
not visible by day 84. Treated horses used limb by 42 days whereas controls did
not bear weight even by 42 days. Healing was scored 1-6 and compared with
controls treated horses scored 60-76% (P < 0.05).
Key words: Bone morphogenic protein, healing,
horse.