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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 27 (3): 139-145, 2023.
Mutations of exon 2 in bone morphogenetic protein-15 gene and fertility in goats.
Elham Javdan, Jamal Fayazi, Mohammad Taghi Baigi Nasiri, Saleh Tabatabaei
Department of Animal Science, Ramin University of Agriculture and Natural Resources, Ahwaz, Iran
Javdan E, Fayazi J, Baigi Nasiri MT, Tabatabaei S., Mutations of exon 2 in bone morphogenetic protein-15 gene and fertility in goats, Onl J Vet Res., 27 (3): 139-145, 2023. We report polymorphisms of BMP15 gene and fertility in goats by PCR- polymerase chain reaction-single-strand conformation polymorphism (SSCP). One hundred seventeen genomic DNA samples were obtained from Najdi and Lori-Bakhtiari goats. Genomic DNA was extracted for 235 bp fragments of exon 2 of BMP15 gene amplified by PCR with specific primers assayed by single stranded conformation polymorphism. In Nadji goat we found polymorphisms with genotypes AA with frequency of 0.155, BB 0.167, FF 0.011, DD 0.011, EE 0.123, AD 0.133 and AB frequency of 0.4 whereas in Lori Bakhtiari these values were AA frequency of 0.259, BB 0.075, CC 0.037, DD 0.037, AD 0.185 and AB frequency of 0.407. Heterozygosity in Nadji goats was 0.533 and Lori Bakhtiari 0.593. We find that BMP15 gene folliculogenesis may be associated with litter size of these goats.
Key Words: Bone Morphogenetic Protein 15, Goat, Prolificacy, PCR-SSCP.