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Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X


Volume 28(4): 248-255, 2024.

Sympathetic fibres in urinary bladder of cats with interstitial cystitis


Archivaldo Reche Jr. DVM PhD1, CA Tony Buffington DVM PhD2,

Mitika K Hagiwara DVM PhD1, Alexandre GT Daniel1


1Department of Medical Clinics, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil,2Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, Ohio – USA




Reche Jr. A, Buffington CAT, Hagiwara MK, Daniel AGT., Sympathetic fibres in urinary bladder of cats with interstitial cystitis, Onl J Vet Res., 28(4): 248-255, 2024. We compared sympathetic nervous fibers in normal urinary bladders of 6 cats with 6 cats with interstitial cystitis (IC). Cats were euthanized and perfused trans-cardiac with Krebs-Ringer and 4% paraformaldehyde solutions. Urinary bladders were excised and frozen to -70°C. Tissue slides were processed for immunohistochemistry by avidin-biotin method for neurons containing tyrosine hydroxylase (TH).  We observed increased sympathetic nervous fibers in lamina propria and muscularis in cats with IC compared with controls. TH levels were higher (P < 0.05) in mucosa of bladder apex (26,5 ± 2,7%) with IC than controls (19,7 ± 1,4%), body (28,6 ± 3,4% vs 20,6 ± 3,7%) and neck (31,8 ± 1,3% vs 25,2 ± 3,2%). In muscularis apex (11,2 ± 7,6% vs 7,6 ± 0,6%), body (12,4 ± 1,6% vs 8,3 ± 2,1%) and neck (15,5 ± 0,8% vs 11,8 ±1,6%) .Findings suggested enhanced catechol-aminergic fibers in urinary bladder of cats with IC may induce neurogenic inflammation.


KEY WORDS: interstitial cystitis, cats, tyrosine hydroxylase, urinary bladder.