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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume 28
(10): 726-732, 2024.
Bird Influenza virus biochemistry and mutants
Kumar D, Mittal Y
Department
of Zoology, Government Postgraduate College, Rishikesh,
Uttrakhand. India
ABSTRACT
Kumar D,
Mittal Y. Bird Influenza virus biochemistry
and mutants, Onl J Vet Res., 28 (10): 726-732, 2024. Influenza is a viral disease. By internal matrix
protein bound to ribonucleoprotein of the genome, antigen yielded influenza
viruses A, B and C. The H5N1 genome was found to have eight segments of
ribonucleoprotein of single stranded RNA. Each segment codes for a different
protein. A major problem is faced in vaccine development against surface antigens
because the virus has a very rapid mutation rate. The PB2 gene of segment 1 seems
to give an insight to developing a peptide based vaccine for the treatment of
bird flu because of a significant mutation at 627 position which has changed
the Lys (K) of H1N1 to Glu (E) in H5N1
K627E mutation.
KEY-WORDS:
Influenza virus, Mutations, Bird Flu.
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