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OJVRTM

Online Journal of Veterinary Research

 

Volume 25(2): 96-105, 2021.


Bird flu H5N1 virus biochemical and mutational characteristics for vaccine development.

 

Kumar D and Mittal Y.

 

Department of Zoology, Government Postgraduate College, Rishikesh, Uttrakhand. India

 

ABSTRACT

Kumar D, Mittal Y., Bird flu H5N1 virus biochemical and mutational characteristics for vaccine development, Onl J Vet Res., 25(2): 90-98, 2021. Influenza viruses include A, B and C types based on internal antigen matrix protein binding to ribonucleoprotein of the genome. Influenza virus A with pandemic potential consists of 16H and 9N subtypes based on surface antigens hemagglutinin and neuraminidase. The H5N1 genome was found to have 8 segments of ribonucleoprotein of single stranded RNA each coding for a different protein. A major problem for vaccine development against influenza surface antigens is due to very rapid mutations. However we find that PB2 gene of segment 1 may be useful for peptide based vaccine for bird flu because of a significant mutation at 627 position from Lys (K) of H1N1 to Glu (E) in H5N1 K627E mutation.

KEY-WORDS: Influenza virus, Mutations, Bird Flu.


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