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OJBTM
Online Journal of Bioinformatics ©
Volume 8 (1) : 17-30, 2007
Plasma Proteome Knowledgebase:Exploring Disease Biomarker Correlations
Iyer J, Srinivas
VM, Khamari L, Sequeira JM,
Das N, Periasamy UR, Bhate J
1 Molecular Connections Pvt. Ltd, Kandala
Mansions, #2/2 Kariappa Road (South Cross Road), Basavanagudi, Bangalore – 560004, India
ABSTRACT
Iyer J, Srinivas VM, Khamari L, Sequeira JM, Das N, Periasamy UR, Bhate
J, Plasma Proteome
Knowledgebase: Exploring Disease Biomarker Correlations, Online J
Bioinformatics 8(1) : 17-30, 2007. Blood represents one of the most complex and
dynamic mammalian proteomes. Quantitative analysis of plasma proteome for
disease diagnosis has significant clinical relevance as it could reflect the pathophysiological state of the organism. Thus, a curated database of plasma proteins could aid in analyzing
and interpreting the vast pool of available data. The plasma protein
database that has been developed in-house contains concentration values mined
from literature that reflect alterations between
normal versus disease conditions. In addition, there are significant
differences in the levels of plasma proteins, influenced by genetics, sex, age,
gender, physiological state etc. Analysis of potentially important plasma
protein concentrations compiled in the database has allowed us to identify and
validate potential biomarker-disease associations. A comprehensive, easy to access
plasma protein database with defined concentration values has been created, and
the process involved in its development is described. The plasma catalog
provides a concise snapshot of more than 500 clinically significant proteins,
the concentration range reflecting the pathophysiological
state of the organism
Key Words:
database, plasma, proteome, diagnosis, biomarker, concentration, disease
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