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OJBTM
Online Journal
of
Bioinformatics
©
Evolutionary
map of lateral gene transfer in biofilm-forming human
pathogenic microorganisms
Nidhi
Mathur, Ravneet Chug
Amity Institute of
Biotechnology, Amity University,
Rajasthan.
ABSTRACT
Mathur N, Chug R., Evolutionary
lineage of lateral gene transfer
in biofilm-forming human pathogenic microorganisms, Onl
J Bioinform., 14 (2):
160-167, 2013. Biofilms secreted by microbes in
human infections create
densely packed communities of cells that grow on living or
inert surfaces. The
microbes survive as a common entity to adapt to the
environment and express
specific genes. 16s
rRNA
gene sequences from 17 biofilm forming bacteria pathogenic to
humans were
extracted from GenBank.
Phylogenetic analysis revealed
that the microbes belonged to Legionella,
Staphylococcus and Alteromonas
groups. Legionella
pneumophila
was the oldest
closely related to
a common ancestor. Protein auto-induction in 12 and
15 hemolytic toxin
of 17 bacteria evolved earliest in Salmonella
sp. Mycobacterium
tuberculosis
was the most evolved
microbe. Lateral
Gene Transfer was evident in many groups due to a patchy,
scattered
phylogenetic tree.
Key-words: Biofilms,
pathogenesis, phylogenetic analysis, toxicogenesis,16s
rRNA.