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OJVRTM
Online Journal of Veterinary Research©
Volume
18(3): 278-286, 2014. Redacted 2017.
Effects of
ventromedial hypothalamic nucleus cannulated serotonin on bile secretion and
lipid metabolism in Wistar rats
Mona Rahdar1, Javad Sajedianfard1, Saeed Nazifi2, Fatemeh
Azizi-Farsani1
Department(s) of 1Physiology and 2Clinical Pathology, School
of Veterinary Medicine, Shiraz University, Iran
ABSTRACT
Rahdar M, Sajedianfard
J, Nazifi S, Azizi-Farsani F.,
Effects of ventromedial hypothalamic nucleus serotonin on bile secretion and
lipid metabolism in Wistar rats, Onl
J Vet Res., 18(3):
278-286, 2014. The ventromedial
hypothalamic nucleus (VMH) regulates gastrointestinal activity and lipid
metabolism. The effect of serotonin (5-HT) cannulo-injected
into VMH on bile secretion, serum lipid levels and hepatic enzymes in Wistar rats is described. Thirty male Wistar
rats were cannulated in the VMH for administration of 1 µl 5-HT. One week
after, the common bile duct was cannulated and bile blood samples were
collected every 15 min for 60 min after the administration of 5-HT. Centrally
applied 5-HT increased bile secretion at all studied periods and decreased
LDL-cholesterol (LDL-c) level. Present findings suggest that 5-HT participates
in the central regulation of bile secretion in the rat, and that the VMH could
be a site regulating bile secretion and blood lipid levels.
Keywords:
Serotonin, Bile flow, VMH, Serum lipids, Hepatic enzymes
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