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Online Journal of Veterinary Research

Volume 24 (11): 629-633, 2020.


Serum bile acids and enzyme levels in rats exposed to inhaled trichlorethylene

 

Guerrini VH DVM, MVSc, MCs, PhD.

SUMMARY

 

Guerrini V. H. Serum bile acids and enzyme levels in rats exposed to inhaled trichloroethylene, Onl J Vet Res., 24(11):629-633, 2020., Behaviour, body weight, serum aspartate aminotransferase (AST) alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin and total and individual serum bile acid concentrations (SBA) were determined in Sprague Dawley rats exposed to various normal levels of trichloroethylene (TRI) concentrations ranging from 0 to 200 ppm 6hr/day for 5 days or three 5 day weeks. The exposures produced consistent increases in ALP but not in SBA. There was a large range in the concentrations of SBA in controls (1 to 46 ug/L) and those exposed to 4 to 157 ug/L. Results suggest that ALP but not SBA may be a useful marker of cellular changes in rats inhaling current exposure standard levels of industrial solvents such as TRI.

 

Key Words: Trichloroethylene, exposure, bile acids, rat.


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