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OJVR TM
Online Journal of Veterinary Research ©
Volume 24 (11): 629-633, 2020.
Serum bile acids and enzyme levels in rats
exposed to inhaled trichlorethylene
Guerrini VH DVM, MVSc, MCs, PhD.
SUMMARY
Guerrini V. H.
Serum bile acids and enzyme levels in rats exposed to inhaled
trichloroethylene, Onl J Vet Res., 24(11):629-633,
2020., Behaviour, body weight, serum aspartate
aminotransferase (AST) alanine aminotransferase (ALT), alkaline phosphatase
(ALP), bilirubin and total and individual serum bile acid concentrations (SBA)
were determined in Sprague Dawley rats exposed to various normal levels of
trichloroethylene (TRI) concentrations ranging from 0 to 200 ppm 6hr/day for 5
days or three 5 day weeks. The exposures produced consistent increases in ALP
but not in SBA. There was a large range in the concentrations of SBA in
controls (1 to 46 ug/L) and
those exposed to 4 to 157 ug/L. Results suggest that
ALP but not SBA may be a useful marker of cellular changes in rats inhaling current
exposure standard levels of industrial solvents such as TRI.
Key Words: Trichloroethylene, exposure, bile acids,
rat.
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