2020-2032 All Rights Reserved.  Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors.


Online Journal of Veterinary Research

Volume 24 (11): 629-633, 2020.

Serum bile acids and enzyme levels in rats exposed to inhaled trichlorethylene


Guerrini VH DVM, MVSc, MCs, PhD.



Guerrini V. H. Serum bile acids and enzyme levels in rats exposed to inhaled trichloroethylene, Onl J Vet Res., 24(11):629-633, 2020., Behaviour, body weight, serum aspartate aminotransferase (AST) alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin and total and individual serum bile acid concentrations (SBA) were determined in Sprague Dawley rats exposed to various normal levels of trichloroethylene (TRI) concentrations ranging from 0 to 200 ppm 6hr/day for 5 days or three 5 day weeks. The exposures produced consistent increases in ALP but not in SBA. There was a large range in the concentrations of SBA in controls (1 to 46 ug/L) and those exposed to 4 to 157 ug/L. Results suggest that ALP but not SBA may be a useful marker of cellular changes in rats inhaling current exposure standard levels of industrial solvents such as TRI.


Key Words: Trichloroethylene, exposure, bile acids, rat.