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Online Journal of Veterinary Research©


Volume 26 (5): 352-356, 2022.

Effect of bifidobacteria on bone density and loss in male Wistar rats.


Taghian Mehdi1, Motaghi Ehsan2, Najarian Mojtaba3, Ghasemi, Masumeh4


1Torabinejad Dental Research Center, Department Of Oral And Maxillofacial Surgery, School Of Dentistry, Isfahan University Of Medical Sciences, 2Pharmacology Department, Pharmacy School, Medical University Of Isfahan, 3Department Of Oral And Radiology, Dental School, Medical University Of Isfahan, 4Inmunology Department, Medical School, Medical University Of Shahrekord, Iran.



Mehdi T, Ehsan M, Mojtaba N, Masumeh G., Effect of bifidobacteria on bone density and loss, Onl J Vet Res., 26 (5): 352-356, 2022. We describe effect of probiotics on bone density and loss in Wistar rats. Groups of 9 rats each were gavaged 109 Bifidobacterium infantis daily for 70 days and first mandibular molars then ligated. Un-ligated contralateral molar were used as controls. Rats were sacrificed 30 days after ligature and mandibules removed to determine bone loss and density compared to controls. The mandibles were defleshed and stained with 1% methylene blue and bone loss from cemen­t-enamel junction to the alveolar bone crest was measured. Bone loss between furcation  roof and bone  crest and density of alveolar bone were then determined. We found 46-49% bone loss in ligated teeth compared with un-ligated ones with or without probiotic. However, ligation or probiotic had no effect on bone loss in ligated teeth.


Key words: Periodontitis, Bifidobacterium infantis, bone loss, density, teeth,