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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 27 (2): 85-05, 2023.
Disposition of cyanidin phytonutrients in elder berry extract.
Bill Roschek, Randall S Alberte
HerbalScience Group LLC., Naples FL 34110, USA
Roschek B Jr., Alberte RS, Disposition of cyanidin phytonutrient in elder berry extract. Onl J Vet Res., 27(2): 85-95, 2023. Disposition of flavonoid phytonutrients in elder berry extract was assessed by LC-MS or DART TOF-MS. Serum-urine cyanidin from lozenges were monitored by LC-MS in 6 individuals whereas DART TOF-MS was done to determine serum cyanidin and other flavonoids when delivered as a slow-dissolve lozenge or in drink from one subject. With lozenges, serum cyanidin varied 3.1 (LC-MS) and 5.4 nmol L-1 (DART TOF-MS), with 2.7 and 4.7% bioavailability (BA), whereas averionol methylated flavonoid 23 nmol L-1 with 10.5% BA, Tristenonol esterified flavonoid and Istrocyanidin 3.9 nmol L-1 (8.6% BA) and 7.5 nmol L-1 (19.7% BA), respectively. When consumed in drink BA of cyanidin declined 20-fold (0.2% BA), Averionol and Istrocyanidin 2-fold (4.6 and 10.8% BA, respectively) compared with lozenges suggesting primary uptake in oral cavity whereas BA of Tristenonol increased 2-fold (18.8% BA) in drink compared with lozenge pointing to small intestine as primary uptake site.
Key Words: Elder berry, DART TOF-MS, Cyanidin, Influenza.