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Online Journal of Veterinary Research©
Volume 22 (9):784-788, 2018.
Effect of intraperitoneal versus oral drench of beta-amino butyric acid
on hematology and immunoglobulin in Sprague Dawley rats.
Mohammed Abbas Jassim, Iman Naji Saleh.
College of Education for Women, University of Anbar.
Jassim MA, Saleh IN., Effect of intraperitoneal versus oral drench of beta-amino butyric acid on hematology and immune markers in Sprague Dawley rats, Onl J Vet Res., 22 (9):784-788, 2018. Beta-β-amino acids form peptide chains which enhance bioavailability of pharmaceuticals. We report effect of intraperitoneal versus oral drench of beta-amino butyric acid (BABA) on hematology and immune markers in Sprague Dawley male rats. Groups of 5 rats each were injected intraperitoneally or drenched with 1, 0.5 and 0.25 g/kg BABA weekly for 4 weeks. Five controls were injected IP or drenched saline weekly. At 4 weeks, blood was taken for hematology and animals were sacrificed for microscopy. Compared with controls there were significant increases (P <0.01) in red blood cells, hemoglobin and packed cell volumes in those injected BABA at any concentration. Total white blood cells increased (P < 0.01) in injected and drenched BABA but only at higher concentrations, whereas lymphocytes, monocytes, basophils, eosinophils and neutrophils increased at any concentration. We found increased (P < 0.01) immunoglobulin (IgG) rats in drenched or injected BABA. Our results simulate those of GABA in rats
Keywords: non-protein amino acids' BABA, immunoglobulins. Raw data provided.