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OJVRTM
Online Journal of Veterinary Research©
Established 1994
ISSN 1328-925X
Volume 22 (9):784-788, 2018.
Effect of intraperitoneal
versus oral drench of beta-amino butyric acid
on hematology and
immunoglobulin in Sprague Dawley rats.
Mohammed Abbas Jassim, Iman Naji Saleh.
College
of Education for Women, University of Anbar.
ABSTRACT
Jassim MA, Saleh IN., Effect of
intraperitoneal versus oral drench of beta-amino butyric acid on hematology and
immune markers in Sprague Dawley rats, Onl J Vet Res.,
22 (9):784-788, 2018. Beta-β-amino
acids form peptide chains which enhance bioavailability of pharmaceuticals. We
report effect of intraperitoneal versus oral drench of beta-amino butyric acid
(BABA) on hematology and immune markers in Sprague Dawley male rats. Groups of
5 rats each were injected intraperitoneally or drenched with 1, 0.5 and 0.25
g/kg BABA weekly for 4 weeks. Five controls were injected IP or drenched saline
weekly. At 4 weeks, blood was taken for hematology and animals were sacrificed
for microscopy. Compared with controls there were significant increases (P
<0.01) in red blood cells, hemoglobin and packed cell volumes in those
injected BABA at any concentration. Total white blood cells increased (P <
0.01) in injected and drenched BABA but only at higher concentrations, whereas
lymphocytes, monocytes, basophils, eosinophils and neutrophils increased at any
concentration. We found increased (P < 0.01) immunoglobulin (IgG) rats in
drenched or injected BABA. Our results simulate those of GABA in rats
Keywords: non-protein
amino acids' BABA, immunoglobulins. Raw data provided.
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