1994-2019. All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors.


OJVRTM

     Online Journal of Veterinary Research

Established 1994 
ISSN 1328-925X

 

Volume 22 (9):784-788, 2018.


Effect of intraperitoneal versus oral drench of beta-amino butyric acid

on hematology and immunoglobulin in Sprague Dawley rats.

 

Mohammed Abbas Jassim, Iman Naji Saleh.

 

College of Education for Women, University of Anbar.

 

ABSTRACT

 

Jassim MA, Saleh IN., Effect of intraperitoneal versus oral drench of beta-amino butyric acid on hematology and immune markers in Sprague Dawley rats, Onl J Vet Res., 22 (9):784-788, 2018. Beta-β-amino acids form peptide chains which enhance bioavailability of pharmaceuticals. We report effect of intraperitoneal versus oral drench of beta-amino butyric acid (BABA) on hematology and immune markers in Sprague Dawley male rats. Groups of 5 rats each were injected intraperitoneally or drenched with 1, 0.5 and 0.25 g/kg BABA weekly for 4 weeks. Five controls were injected IP or drenched saline weekly. At 4 weeks, blood was taken for hematology and animals were sacrificed for microscopy. Compared with controls there were significant increases (P <0.01) in red blood cells, hemoglobin and packed cell volumes in those injected BABA at any concentration. Total white blood cells increased (P < 0.01) in injected and drenched BABA but only at higher concentrations, whereas lymphocytes, monocytes, basophils, eosinophils and neutrophils increased at any concentration. We found increased (P < 0.01) immunoglobulin (IgG) rats in drenched or injected BABA. Our results simulate those of GABA in rats

 

Keywords: non-protein amino acids' BABA, immunoglobulins. Raw data provided.


MAIN

 

FULL-TEXT (SUBSCRIBE OR PURCHASE TITLE $35USD)