©2021-2033.
All Rights Reserved. Online Journal of Veterinary Research .
You may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJVR. This article may be
copied once but may not be, reproduced or re-transmitted without the express
permission of the editors. This journal satisfies the refereeing requirements
(DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or
any pages linking to this page you must link directly to this page only here
rather than put up your own page.
OJVRTM
Online Journal of
Veterinary Research©
(Including Medical
and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 27 (1): 46-52, 2023.
Effect
of Phoenix dactylifera dates and atorvastatin on blood
glucose, lipids and liver histology in hyperlipidemic
male Wistar rats
Nadia KJ
Al-Dawah, Shatha Mousa Mlaghee Alsafi,
Saadia Saleh Mehdy Zieny
Department of Physiology, Pharmacology and Chemistry, Faculty of
Veterinary Medicine, University of Kufa, Iraq.
ABSTRACT
Al-Dawah NKJ, Mlaghee
Alsafi SM, Mehdy Zieny SS., Effect of Phoenix dactylifera
and atorvastatin on blood glucose, lipids and liver histology in hyperlipidemic male Wistar rats, Onl J Vet Res., Onl J Vet
Res., 27 (2): 46-52, 2023. Authors report effect of phoenix dactilifera dates and seeds and atorvastatin
supplements on blood glucose, lipids and liver histology in hyperlipemic
Wistar male rats. For dietary supplements, phoenix dactilifera
fruit or dried seed powder was mixed with ~20% feed or 20mg/kg atorvastatin in
drinking water. We used groups of six adult ~200g twelve week old male Wistar rats. We
induced hyperlipidemia in 24 rodents with 0.5mg of cholesterol gavaged daily for
60 days. After, five groups of 6 hyperlipidemic rats
each were supplemented daily for 28 days. Untreated normal and non-treated hyperlipemic rats served as controls. Compared with controls,
in non-treated hyperlipidemic controls, serum triglicerides (TG) increased 74%, cholesterol 33%, very low
(VLDL) 61% and low densities lipoproteins 75% and glucose 61%. In hyperlipidemic rats given P dactilira date fruit TG rose 40% but in
those given seed powder remained normal. With exception of very low density
lipoprotein, in all rats given P dactilira date fruit or seeds, serum lipids and glucose
remained normal. In rats given atorvastatin TG rose 57%, cholesterol 17%, VLDL
23% and glucose 34%. Findings suggest that date fruit or seed may prevent hyperlipidemia,
glucosuria and liver fatty degeneration.
Keywords: Hyperlipidemia, Phoenix dactylifera, fruit, seed, Atorvastatin.
FULL-TEXT (SUBSCRIBE OR
PURCHASE TITLE)