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OJVRTM

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X

 

Volume 27 (1): 46-52, 2023.


Effect of Phoenix dactylifera dates and atorvastatin on blood glucose, lipids and liver histology in hyperlipidemic male Wistar rats

 

Nadia KJ Al-Dawah, Shatha Mousa Mlaghee Alsafi, Saadia Saleh Mehdy Zieny

 

Department of Physiology, Pharmacology and Chemistry, Faculty of Veterinary Medicine, University of Kufa, Iraq.

 

ABSTRACT

 

Al-Dawah NKJ, Mlaghee Alsafi SM, Mehdy Zieny SS., Effect of Phoenix dactylifera and atorvastatin on blood glucose, lipids and liver histology in hyperlipidemic male Wistar rats, Onl J Vet Res., Onl J Vet Res., 27 (2): 46-52, 2023. Authors report effect of phoenix dactilifera dates and seeds and atorvastatin supplements on blood glucose, lipids and liver histology in hyperlipemic Wistar male rats. For dietary supplements, phoenix dactilifera fruit or dried seed powder was mixed with ~20% feed or 20mg/kg atorvastatin in drinking water. We used groups of six adult ~200g twelve week old male Wistar rats. We induced hyperlipidemia in 24 rodents with 0.5mg of cholesterol gavaged daily for 60 days. After, five groups of 6 hyperlipidemic rats each were supplemented daily for 28 days. Untreated normal and non-treated hyperlipemic rats served as controls. Compared with controls, in non-treated hyperlipidemic controls, serum triglicerides (TG) increased 74%, cholesterol 33%, very low (VLDL) 61% and low densities lipoproteins 75% and glucose 61%. In hyperlipidemic rats given P dactilira date fruit TG rose 40% but in those given seed powder remained normal. With exception of very low density lipoprotein, in all rats given P dactilira date fruit or seeds, serum lipids and glucose remained normal. In rats given atorvastatin TG rose 57%, cholesterol 17%, VLDL 23% and glucose 34%. Findings suggest that date fruit or seed may prevent hyperlipidemia, glucosuria and liver fatty degeneration.

 

Keywords: Hyperlipidemia, Phoenix dactylifera, fruit, seed, Atorvastatin.


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