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OJVRTM
Online Journal of Veterinary Research©
Volume 18(10):
785-789, 2014. Redacted 2018.
In vitro effect of Artemisia santolina extracts
on motility and survival of Haemonchus contortus
Nouri
Fatemeh1, Nourollahi-Fard Saied R2,
Kowsari Nasim 3,
Sharifi Hamid4,5.
1Pharmacology Department, School
of Medicine, Iran University of Medical Sciences, Tehran, 2,3,Faculty of Veterinary Medicine, Shahid Bahonar University of
Kerman, 4,5Research Center for Modeling in Health,
Institute for Future Studies in Health, Kerman University of Medical Sciences,
Kerman, Iran
ABSTRACT
Nouri F, Nourollahi-Fard Saied R, Kowsari
N, Sharifi H. In vitro effect of Artemisia santolina
extracts on motility and survival of Haemonchus contortus, Onl J Vet Res.,
18(10): 785-789, 2014. In small ruminants, the abomasal parasite Haemonchus contortus induces normocytic-hypochromic anemia and
weight loss. Because of increasing resistance to current anthelminths,
residues and high costs, extracts of medicinal plants are being tested as
alternatives. In vitro anthelmintic
activity of dried Artemisia santolina aqueous and ethanolic
extracts on Haemonchus contortus
were compared with levamisole. Fifty mature Haemonchus contortus were exposed to Artemisia santolina
25, 50 and 75 mg/ml aqueous and ethanolic extracts
for 10 hours at 25°C. PBS buffer was used as negative control, 50mg/ml levamisole
as positive control and 5mg/ml levamisol as a
standard. A worm motility inhibition assay and survival analysis using the Cox
proportional hazard model were used for data analysis. Extracts of Artemisia santolina
reduced (P < 0.05) Haemonchus contortus motility
and survival in a time and dose dependent manner. Compared with levamisole, the
ethanolic extract had greater (P < 0.05) anti-helminth
effect whereas the aqueous extract less.
Keywords: Artemisia santolina, Haemonchus contortus, Levamisole,
Anthelmintic.
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