©2021-2033. All Rights Reserved. Online Journal of Veterinary Research . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.
Online Journal of Veterinary Research©
Volume 26 (6): 458-463, 2022.
Effect of Echium amoenum on anxiety and convulsion markers in Balb C mice
Hooman Bozorgi*1, Ehsan Motaghi2, Zahra Chizari3 and Mehdi Taghian4
1,2 Department of Pharmacology, School of Pharmacy, 3Parasitology, School of Medicine, Isfahan University of Medical Sciences 4Torabinejad Dental Research Center, Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences.
Bozorgi H, Motaghi E, Chizari Z, Taghian M., Effect of Echium amoenum on anxiety and convulsion markers in Balb C mice, Onl J Vet Res., 26 (6): 458-463, 2022. Three groups of 8 male balb c mice were placed in open arm at center of Z maze for recording of entries and time spent every 5 minutes. One group were then injected 50mg/kg Echium amoenum anthocianin extract intraperitoneally (IP), then placed 30 minutes later in infrared apparatus to assess locomotor activity every 5-min for 15 min. Sham controls were given 0.5 mg/kg diazepam IP or 40mg/kg phenobarbital. Compared with controls, the extract boosted time and arm entries but reduced time in closed arms ~21% (P < 0.05). The extract showed no effect on duration of tonic hind limb extension. Locomotor activity was affected but not to the same dfegree as diazepam. We find that extract of E. amoenum may induce an anxiolytic response but had no effect on convulsions in mice.
Keywords: Echium amoenum, Anthocyanin, Anxiety, Convulsion, mice.