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OJVRTM
Online Journal of
Veterinary Research©
Volume 26 (6): 458-463, 2022.
Effect of Echium amoenum on anxiety
and convulsion markers in Balb C mice
Hooman Bozorgi*1, Ehsan Motaghi2, Zahra
Chizari3 and Mehdi Taghian4
1,2 Department of Pharmacology, School of Pharmacy, 3Parasitology,
School of Medicine, Isfahan University of Medical Sciences 4Torabinejad Dental Research Center, Department of
Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of
Medical Sciences.
ABSTRACT
Bozorgi H, Motaghi E, Chizari
Z, Taghian M., Effect of Echium amoenum on
anxiety and convulsion markers in Balb C mice, Onl J Vet Res., 26
(6): 458-463, 2022. Three
groups of 8 male balb c mice were placed in open arm at center of Z maze for recording
of entries and time spent every 5 minutes. One group were then injected 50mg/kg
Echium amoenum anthocianin extract intraperitoneally
(IP), then placed 30 minutes later
in infrared apparatus to assess locomotor activity every 5-min for 15 min. Sham
controls were given 0.5 mg/kg diazepam IP or 40mg/kg phenobarbital. Compared
with controls, the extract boosted time and arm entries but reduced time in
closed arms ~21% (P < 0.05). The extract showed no effect on duration of
tonic hind limb extension. Locomotor
activity was affected but not to the same dfegree as
diazepam. We find that extract of E. amoenum may
induce an anxiolytic response but had no effect on convulsions in mice.
Keywords: Echium amoenum, Anthocyanin,
Anxiety, Convulsion, mice.
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