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Online Journal of Veterinary Research


Volume 26 (6): 458-463, 2022.

Effect of Echium amoenum on anxiety and convulsion markers in Balb C mice


Hooman Bozorgi*1, Ehsan Motaghi2, Zahra Chizari3 and Mehdi Taghian4


1,2 Department of Pharmacology, School of Pharmacy, 3Parasitology, School of Medicine, Isfahan University of Medical Sciences 4Torabinejad Dental Research Center, Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences.



Bozorgi H, Motaghi E, Chizari Z, Taghian M., Effect of Echium amoenum on anxiety and convulsion markers in Balb C mice, Onl J Vet Res., 26 (6): 458-463, 2022. Three groups of 8 male balb c mice were placed in open arm at center of Z maze for recording of entries and time spent every 5 minutes. One group were then injected 50mg/kg Echium amoenum anthocianin extract intraperitoneally (IP), then placed 30 minutes later in infrared apparatus to assess locomotor activity every 5-min for 15 min. Sham controls were given 0.5 mg/kg diazepam IP or 40mg/kg phenobarbital. Compared with controls, the extract boosted time and arm entries but reduced time in closed arms ~21% (P < 0.05). The extract showed no effect on duration of tonic hind limb extension. Locomotor activity was affected but not to the same dfegree as diazepam. We find that extract of E. amoenum may induce an anxiolytic response but had no effect on convulsions in mice.

Keywords: Echium amoenum, Anthocyanin, Anxiety, Convulsion, mice.