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OJVRTM
Online Journal of Veterinary Research©
Volume 17 (11):642-648, 2013. Redacted 2017.
Anxiolytic and
anticonvulsant properties of Anthocyanin extract of Echium
amoenum in mice
Hooman Bozorgi*1, Ehsan Motaghi2, Zahra
Chizari3 and Mehdi Taghian4
1 2Department(s) of Pharmacology,
School of Pharmacy, 3Parasitology, School of Medicine,
4Torabinejad Dental Research Center, Oral and
Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical
Sciences
ABSTRACT
Bozorgi H, Motaghi E, Chizari Z, Taghian M., Anxiolytic
and anticonvulsant properties of anthocyanin extract of Echium
amoenum in mice, Onl J Vet
Res., 17 (11):642-648, 2013. Anthocyanin extract of Echium amoenum flowers was given intraperitoneally (IP) to mice at a dose of 50mg/kg. Sedative and anxiolytic effects of Echium were compared with mice vehicle and
diazepam controls. There was increased time-spent and arm entries in open arms
but reduced time-spent in closed arms of elevated plus-maze (EPM) in mice given Echium. The extract had no significant effect on drug test duration of tonic
hind limb extension (THE) compared with vehicle controls. Locomotor activity
was reduced compared with vehicle but not diazepam mice controls. Results
suggest that Echium
may have sedative properties but diazepam sedation was more severe. Anthocyanin
extract of E. amoenum could have anxiolytic
but not anticonvulsant activity in a mice model. The active constituents of the
Echium
should be isolated and tested for anxiolytic and anticonvulsant properties.
.
KEYWORDS: Echium
amoenum,
Anthocyanin, Anxiety, Convulsion
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