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Online Journal of Veterinary Research©
24(7): 413-419, 2020.
Effect of Anethum graveolens (Dill seed) alcohol extract on liver function in hypomagnesemic rats.
Yasmine Alla Aldeen Abdalmajeed, Luma Waleed Khaleel
Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Bagdad
Aldeen Abdalmajeed YA, Khaleel LW., Effect of Anethum graveolens (Dill seed) alcohol extract on liver function in hypomagnesemic rats, Onl J Vet Res., 24(7): 413-419, 2020. Authors induced hypomagnesemia in male wistar rats with 1.39gm/kg oral potassium chloride (KCl). Groups of 10 rats each were then gavaged 700mg/kg dill seed extract with or without 0.1mg/kg magnesium (Mg) sulphate IM daily for 45 days. Controls were given water. Fasting cardiac blood was taken at 45 days for serum liver enzymes, magnesium, potassium (K), Malondehyde (MDA) and glutathione (GSH). At day 45, liver tissue was excised for immunohistochemistry. In rats given only KCl, serum Mg declined ~36% and K increased ~29%, aspartate and alanine transaminases increased ~41-44% and GGT ~36% (P < 0.05). We found no significant changes in serum values in rats given KCl with dill or magnesium. However, potassium also declined in rats given KCl with dill or magnesium (~-21%). MDA increased ~37% and GSH declined ~-24%. Hepatocytes of rats given KCl reacted with intense cytoplasmic and nuclear staining with apoptosis whereas in those given dill we observed less staining with structural integrity or no apoptosis. In those given magnesium with KCl we observed moderate increase in nuclear and cytoplasmic staining. Our results suggest that Dill may have inhibited liver damage in rats with hypomagnesemia.
Key words: Hypomagnesemia, rats, liver enzymes, hepatocyte immunochemistry, Dill seed extract.