2020-2032. All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


Online Journal of Veterinary Research

24(7): 413-419, 2020.

Effect of Anethum graveolens (Dill seed) alcohol extract on liver function in hypomagnesemic rats.


Yasmine Alla Aldeen Abdalmajeed, Luma Waleed Khaleel


Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Bagdad



Aldeen Abdalmajeed YA, Khaleel LW., Effect of Anethum graveolens (Dill seed) alcohol extract on liver function in hypomagnesemic rats, Onl J Vet Res., 24(7): 413-419, 2020. Authors induced hypomagnesemia in male wistar rats with 1.39gm/kg oral potassium chloride (KCl). Groups of 10 rats each were then gavaged 700mg/kg dill seed extract with or without 0.1mg/kg magnesium (Mg) sulphate IM daily for 45 days. Controls were given water. Fasting cardiac blood was taken at 45 days for serum liver enzymes, magnesium, potassium (K), Malondehyde (MDA) and glutathione (GSH). At day 45, liver tissue was excised for immunohistochemistry. In rats given only KCl, serum Mg declined ~36% and K increased ~29%, aspartate and alanine transaminases increased ~41-44% and GGT ~36% (P < 0.05). We found no significant changes in serum values in rats given KCl with dill or magnesium. However, potassium also declined in rats given KCl with dill or magnesium (~-21%). MDA increased ~37% and GSH declined ~-24%. Hepatocytes of rats given KCl reacted with intense cytoplasmic and nuclear staining with apoptosis whereas in those given dill we observed less staining with structural integrity or no apoptosis. In those given magnesium with KCl we observed moderate increase in nuclear and cytoplasmic staining. Our results suggest that Dill may have inhibited liver damage in rats with hypomagnesemia.

Key words: Hypomagnesemia, rats, liver enzymes, hepatocyte immunochemistry, Dill seed extract.