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OJVRTM
Online Journal of Veterinary Research©
Volume 18(9):
735-742, 2014.
Case study: Anaplastic
astrocytoma in a dog
Elisângela Olegário da Silva DVM MSc1*; Bruno César Elias DVM2;
Lucas Alécio Gomes DVM, PhD 3; Ana Paula F.R.L. Bracarense 4DVM,
PhD 4
1Laboratory of Animal
Pathology, 2,3Department of Veterinary Clinics, 4Laboratory
of Animal Pathology, Universidade Estadual de Londrina, 86051-990, Londrina-PR,
Brazil. *Corresponding author: elivet02@gmail.com
ABSTRACT
Olegário da Silva E, César Elias B, Alécio Gomes L, Bracarense AP.,
Case study: Anaplastic astrocytoma in a dog, Onl J
Vet Res., 18(9):
735-742, 2014. An adult male Boxer dog with a history of chronic
otitis media in the left ear and seizures was submitted for medical therapy.
The seizures were progressive and the owner opted for euthanasia. Grossly,
there was a whitish mass at white matter of the parietal region near the
lateral ventricle. Histopathological examination showed proliferation of
atypical cells, ranging from hyperchromatic round cells to bizarre
multinucleated cells with vesicular nuclei, a large and conspicuous nucleolus,
high mitotic activity and atypical mitotic figures. Immuno-histochemical
analysis revealed multifocal weak positive immune-staining for glial fibrillary acidic
protein and S100 protein, multifocal and
moderate for vimentin and negative immunostaining for cytokeratin and p53. The percentage of immunostained
cells for Ki-67 was 9.6%. A definitive diagnosis of anaplastic astrocytoma was
based on the histopathological and immuno-histochemical features.
Key words: anaplastic astrocytoma, brain, dog.
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