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OJVRTM
Online Journal of
Veterinary Research©
12 (2) :59-66, 2008. Editors
note: Extensive Redaction 2018.
Phagocytosis of Pasteurella multocida B:2 by alveolar macrophages and neutrophils in calves.
Trang
CTH, Zamri-Saad M, Noordin MM, Jasni S
Faculty of Veterinary Medicine, Universiti
Putra Malaysia, 43400 Serdang, Malaysia.
ABSTRACT
Trang CTH, Zamri-Saad M, Noordin MM, Jasni S, Phagocytosis of Pasteurella
multocida B:2 by alveolar macrophages in calves. Onl J Vet Res., 12 (2):59-66, 2008.
Clinical signs, pathology, changes in the respiratory tract and phagocytosis by
alveolar macrophages and neutrophils of wild-type and gdhA derivative of Pasteurella multocida B:2 following intratracheal inoculation in calves were determined 48 h
post-inoculation. Wild-type P. multocida B:2 resulted in clinical signs typical of haemorrhagic
septicaemia, including dullness, fever, mucous nasal
discharge and salivation. Subcutaneous oedema was
obvious at the lower jaw, neck and brisket areas. The lungs, trachea and
epiglottis were congested and oedematous while
associated lymph nodes were congested with petechial haemorrhages.
These changes were not observed in calves inoculated
with gdhA derivative of P. multocida B:2. There was significant
(p<0.05) difference in phagocytosis by alveolar macrophages and neutrophils
between calves inoculated with wild-type (45+4.1%) and those inoculated
with gdhA derivative (57+3.4%) of P. multocida B:2.
Key
words: Pasteurella multocida B:2, haemorhagic septicaemia, phagocytosis,
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