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OJVRTM

Online Journal of Veterinary Research

 

Volume 24(11): 665-671, 2020.


Effect of aluminum on behavior tests and brain chemistry in female albino rats.

 

Razan F Hasa, Duraid A Abbas.

 

College of Veterinary Medicine, University of Baghdad, Iraq.

ABSTRACT

 

Hasa RF, Abbas DA., Effect of aluminum on behavior tests and brain chemistry in female albino rats, Onl J Vet Res., 24(11): 665-675, 2020. We report effect of gavaged aluminium on neural behavior and chemical markers in brain homogenate of 3 groups of 8 female albino rats. Rats were gavaged 0.5 or 2.5 mg/kg (5 doses of 0.5mg/kg) daily for 42 days. Controls were given distilled water. Open field, cliff avoidance, swimming, Y maze and negative geotaxis tests were performed to assess behavior. Compared with water controls, in rats given aluminum we found decreased (P < 0.05 for all changes) open field arm entries with 0.5mg/kg (24%) or 2.5mg/kg (46%), defecation increased 66-77% and urination ~66-81%. We found a ~30% decline in acetylcholinesterase in rats given 0.5mg/kg but a 49% increase in those given 2.5mg/kg aluminum. We found large increases (51-62%) in brain homogenate malonyaldehide and large decline (-35 to -64%) in gluthathione in rats given aluminum suggestive of oxidative stress with related free radical damage. Similarly we found increased brain calcium 13-35%, magnesium 49-65%, zinc (29 63%) and AL (19-51%) consistent with release of the components from damaged brain and muscle cells.


Keywords: Aluminum, Neurobehavioral, Neurotransmitter, oxidation.


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