©2020-2032. All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJPK publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.
Online Journal of Veterinary Research©
Volume 24(11): 665-671, 2020.
Effect of aluminum on behavior tests and brain chemistry in female albino rats.
Razan F Hasa, Duraid A Abbas.
College of Veterinary Medicine, University of Baghdad, Iraq.
Hasa RF, Abbas DA., Effect of aluminum on behavior tests and brain chemistry in female albino rats, Onl J Vet Res., 24(11): 665-675, 2020. We report effect of gavaged aluminium on neural behavior and chemical markers in brain homogenate of 3 groups of 8 female albino rats. Rats were gavaged 0.5 or 2.5 mg/kg (5 doses of 0.5mg/kg) daily for 42 days. Controls were given distilled water. Open field, cliff avoidance, swimming, Y maze and negative geotaxis tests were performed to assess behavior. Compared with water controls, in rats given aluminum we found decreased (P < 0.05 for all changes) open field arm entries with 0.5mg/kg (24%) or 2.5mg/kg (46%), defecation increased 66-77% and urination ~66-81%. We found a ~30% decline in acetylcholinesterase in rats given 0.5mg/kg but a 49% increase in those given 2.5mg/kg aluminum. We found large increases (51-62%) in brain homogenate malonyaldehide and large decline (-35 to -64%) in gluthathione in rats given aluminum suggestive of oxidative stress with related free radical damage. Similarly we found increased brain calcium 13-35%, magnesium 49-65%, zinc (29 – 63%) and AL (19-51%) consistent with release of the components from damaged brain and muscle cells.
Keywords: Aluminum, Neurobehavioral, Neurotransmitter, oxidation.