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Online Journal of Veterinary Research©
Volume 22 (6):526-534, 2018.
Effect of acute aluminum chloride toxicity on sperm and reproductive markers in Albino mice.
Anfal Mahdi Mohammed, Bushra Ibrahim AL-Kaisei, Taghreed Jabbar Humadai, Eman Hasham Al-Taee.
Department of Veterinary Pathology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.
Mohammed AM, AL-Kaisei BI, Humadai TJ, Al-Taee EH., Effect of acute aluminum chloride toxicity on sperm and reproductive markers in Albino mice, Onl J Vet Res., 22 (6):526-534, 2018. Effects of intraperitoneal (IP) aluminum chloride (AL) on sperm and testis prostrate and epididymal tissues in Albino mice are reported. Medium lethal dose (LD50) for AL was determined by probit in 8 groups of 9 mice each injected 800 to 1500 mg/kg and estimate to be 1100mg/kg. Other groups of 18 mice each were then injected an IP sub-acute dose of 221.83mg/kg IP, or saline (control) daily for 14 consecutive days. After the 3rd, 7th and 14th day of dosing, groups of 6 mice each were sacrificed for sperm counts and quality and microscopy of testis, prostrate and epididymis. Upon acute toxic exposure, we found significant (P<0.05) increases in defects in sperm with a decrease (P <0.05) by day 14. Microscopy revealed degeneration of cells with necrosis, hemorrhage, congestion, aspermia with lymphocyte and macrophage infiltration especially at day 14.
Key word: AlCl3 toxicity, male Reproductive system, acute toxic exposure, Histopathological changes.