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OJBTM
Online Journal of Bioinformatics ©
Volume 15
(1): 87-97, 2014.
Structure prediction of alpha-synuclein protein and link with neurodegenerative disease.
Rashmika Singh1, 3, Navin K Gaur2, 3,
Ankur Mohan3, Pallavi
Gangwar3
1Institute of Engineering and
Technology, Lucknow, 2Harcourt Butler
Technological Institute, Kanpur, 3Bio-EGICORE (Dept. of Life Science
of EGICORE) Lucknow, India.
ABSTRACT
Singh
R, Gaur NK, Mohan A, Gangwar P., Structure prediction
of alpha-synuclein protein and link with neurodegenerative
disease, Onl J Bioinform., 15(1)87-97,
2014. Neurodegenerative
diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), are a
group of pathologies characterized by a progressive and specific loss of
certain brain areas. The pathogenesis of these disorders centrally involves
abnormal accumulation and aggregation of specific proteins. Pathological
studies showed that Alpha-synuclein protein is
responsible for formation of intraneuronal Lewy bodies and Lewy neuritis
(hallmarks of PD) while others proteins like tau and beta amyloid form
extracellular β-amyloid deposits intracellular neurofibrillary tangles
(hallmarks of AD). However evidence from in vitro and in vivo
studies showed that these proteins are responsible for each other’s aggregation
with different seeding abilities. This idea is taken further to develop a
common therapeutic treatment for both the diseases by targeting alpha synuclein pathologies involved in both of them. Since the
precise structure of alpha synuclein protein is not
yet available. Therefore, a theoretical model of this protein was generated
using homology Modeling. Validation of structure was done by using PROCHECK
available at SAVES server.
Keywords: Alzheimer’s
disease, Parkinson’s disease, SNCA, Homology Modeling, PMDB, SAVES.