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Online Journal of Veterinary Research


Volume 24(9): 511-526, 2020.

Effect of alpha lipoic acid on pesticide induced testicular toxicity in Albino rats.

Azza M Gawish.

Department of Animal Science, Faculty of Science, Cairo University, Giza, Egypt


Gawish AM., Effect of alpha lipoic acid on pesticide induced testicular toxicity in Wistar rats, Onl J Vet Res., 24(9): 511-526, 2020. Author describes effect of alpha-lipoic acid (ALA) on hematology and testicular tissues in groups of 6 rats each gavaged 2mg/Kg 1/60LD50 chloropyrifos, 2.5 mg/km 1/200 LD50 fenitrothion with or without 200mg ALA daily for 28 days. Blood and testis tissue were taken at 14 and 28 days for hematology, histopathology and immunohistochemistry. In rats given pesticides without ALA, we observed mild focal mild testicular hemorrhage, reduced spermatogenesis, necrosis and atrophy. Masson-trichrome stain revealed fibrosis and immunohistochemistry by TUNEL technique revealed apoptotic cells between germ cells. Testes were depleted of acid phosphatase for biosynthesis of testosterone. In rats given ALA with pesticide we found reduced pathology in seminiferous tubules, spermatogenic germ and interstitial cells and fibrosis but no apoptosis. Results suggest that the antioxidant lipoic acid may reduce pesticide toxicity in testes of Wistar rats.



Keywords: Pesticides Reproduction - Apoptosis - Fibrosis Antioxidants.