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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 26 (9): 651-654, 2022..
Effect of Alium cepa flavonoids on metabolism of paracetamol.
K Rajnarayna MPharm PhD, A Venkatesham MPharm PhD, DR Krishna MPharm PhD, Yellu Narsimha Reddy MPharm PhD
Department of Pharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, INDIA -506 009
Rajnarayna K., Venkatesham A, Krishna DR, Reddy YN., Effect of Alium cepa flavonoids on metabolism of paracetamol, Onl J Vet Res., 26 (9): 651-654, 2022. We report effect of oral flavonoids in Alium cepa (onion) on urinary paracetamol and its metabolites in 12 healthy male volunteers. Subjects were given 1000 mg of paracetamol orally and urine levels and metabolites determined 4 to 8h after. After 1 week washout 250g Alium cepa (onion) was ingested and 3h later 1000mg paracetamol. Volunteers were then given 250g A. cepa daily 10 days and on day 11 given 250g before 1000 mg Paracetamol. Results suggest no effect of A cepa 3h before paracetamol on urinary concentrations and metabolites over 8h. However, 10 day daily A cepa reduced paracetamol 57, sulfates 27, cysteins 61 and mercaptans 50%. Flavonoids in A cepa may reduce liver toxicity by scavenging reactive oxygen free radicals produced by paracetamol. We find that ingestion of A cepa onion daily for 10 days or more reduces urinary excretion paracetamol and its metabolites.
Key-words: Paracetamol, Alium cepa, fried onions, metabolism