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OJVRTM
Online Journal of Veterinary Research©
Volume 19(6): 367-378, 2015.
Effect of
oral aflatoxin B1 on histological features in gastrointestinal tract of
broilers.
Isamery Machado1,4, Luis Silva2, Jose
Carabaño2, Elias Ascanio2.5
Antonio Rodríguez2 , Hernando
Rivera- Jimenéz3, Noeme Sousa Rocha4,6
1Agronomia, 2Ciencias
Veterinarias, Universidad Central Venezolana and 3Genetica, Biociencias, 4Ciencias Veterinarias y
Animal Universidad Estadual do Sao
Paulo, Botucatu,
Brasil.
ABSTRACT
Machado
I, Silva L, Carabaño J, Ascanio
E, Rodríguez A , Jimenéz HR, Rocha NS., Effect of
oral aflatoxin B1 on histological features of the gastrointestinal tract of
broilers, Onl J Vet Res., 19(6): 367-378, 2015. Groups
of 5 birds each from birth to 28 days old were fed 100 and 200 μg/kg aflatoxin
B1 with daily feed ration. Controls were fed a ration with non-detectable
levels of aflatoxin. Each treatment consisted of 5 replicates in 5 birds each,
requiring 75 chickens. At sacrifice, esophagus, crop, proventriculus,
gizzard, duodenum, jejunum, and cecal tissue samples
were excised for microscopy. Chickens fed aflatoxin showed hypertrophy and
hyperplasia of glands in the esophagus, thickening of the folds and mononuclear
infiltrate in the mucosa of the proventriculus,
dilated ducts in chorionic adenomeres and ventricles,
epithelial erosion, congestion and swelling of villi in the duodenum and
jejunum. Changes were not detected in the crop or cecum. The findings showed
that chicks fed aflatoxin B1 displayed pathological changes in the digestive
tract.
Keywords: Aflatoxin B1, broilers chickens, digestive tract,
pathological effects.
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