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 Online Journal of Veterinary Research

Volume 22 (7):535-546, 2018.

Effects of Acyclovir on histology of testis and sperm in BALB/C mice.

Buthina Abulhmeed Abdullah, Maryam Mohammed Ali.

Department of pharmacology, College of Veterinary Medicine, Tikrit University, Iraq


Abdullah BA, Ali MM., Effects of Acyclovir on histology of testis and sperm in BALB/C mice, Onl J Vet Res., 22 (7):535-546, 2018. Groups of five 8 week old male BALB/C mice each were gavaged 200, 400 or 800mg/kg Acyclovir (ACV) daily for 30 days and then sacrificed for histopathology of testes and sperm. Controls (n = 5) were gavaged 0.1 ml distilled water. In mice given 200mg/kg we found clots and hemolysis with inflammatory cells, surrounding the testicular capsule, with some abnormal sperms. At higher doses, subcapsular blood vessels appeared congested with hemolysis and the basement membrane of the seminiferous tubules (SNT) appeared degenerated with congestion. Leydig cells appeared atrophied in small masses between the SNT. The parenchyma with SNT revealed hypertrophied spermatogonia detached from the basement membrane with degenerated spermatids throughout. At doses above 200mg/kg we found significant (P < 0.01) increases of morphological abnormalities in sperm with curved and bent tails. ACV at all doses, reduced (P < 0.01) normal sperm and sperm counts compared with controls.

Key Words: Acyclovir, Testis, sperm count, histopathology, mice.