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OJVRTM
Online
Journal of Veterinary Research©
Volume 25 (3): 226-237, 2021.
Effect of quercetin on reproductive markers in rats exposed to chronic lead
toxicity.
Saif Saleem
Ibrahim and Baraa
Njim Al-Okaily
Department of Physiology,
Biochemistry and Pharmacology, College of Veterinary Medicine, University of
Baghdad, Iraq.
ABSTRACT
Ibrahim
SS, Al-Okaily BN., Effect of quercetin on reproductive
markers in rats exposed to chronic lead toxicity, Onl
J Vet Res., 25 (3): 226-237,
2021. Authors
report effect of gavaged quercetin on reproductive
markers in adult female Wistar rats given lead acetate
daily over 35 days. Groups of 10 Wistar rats each were
synchronized for estrus by equine gonadotrophin then gavaged
5mg/kg lead acetate with or without
15mg/kg 95% quercetin daily for 35 days. Controls were given 0.5ml distilled
water. Blood was taken before, 3 and 7 days of estrus. Serum follicular stimulating (FSH), luteinizing (LH), estrogen (E2)
and progesterone (P4) determined by ELIZA. At day 35 rats were sacrificed
for ovarian tissue lead acetate, malondialdehyde (MDA)
and superoxide dismutase (SOD. Compared
with controls, in rats gavaged lead acetate without
quercetin, serum FSH declined (P < 0.05) ~31 to 33% by days 15 and 36,
whereas in those given quercetin, FSH did not vary, but LH declined (P <
0.05) ~-29-32%, estrogen ~-35-39% and progesterone 46-47% In ovarian tissue, lead was 78% higher in rats given only lead and 60%
higher in those given quercetin (P < 0.05), SOD declined ~-55% and ~-34% whereas
MDA increased ~52% and 36%, respectively.
Our results suggest that gavage of quercetin could ameliorate ovarian and or hypothamalic chronic lead acetate toxicity in rats.
Keyword: - quercetin, lead,
hormones, MDA, SOD