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Online Journal of Veterinary Research©
Volume 25 (3): 226-237, 2021.
Effect of quercetin on reproductive markers in rats exposed to chronic lead toxicity.
Saif Saleem Ibrahim and Baraa Njim Al-Okaily
Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Iraq.
Ibrahim SS, Al-Okaily BN., Effect of quercetin on reproductive markers in rats exposed to chronic lead toxicity, Onl J Vet Res., 25 (3): 226-237, 2021. Authors report effect of gavaged quercetin on reproductive markers in adult female Wistar rats given lead acetate daily over 35 days. Groups of 10 Wistar rats each were synchronized for estrus by equine gonadotrophin then gavaged 5mg/kg lead acetate with or without 15mg/kg 95% quercetin daily for 35 days. Controls were given 0.5ml distilled water. Blood was taken before, 3 and 7 days of estrus. Serum follicular stimulating (FSH), luteinizing (LH), estrogen (E2) and progesterone (P4) determined by ELIZA. At day 35 rats were sacrificed for ovarian tissue lead acetate, malondialdehyde (MDA) and superoxide dismutase (SOD. Compared with controls, in rats gavaged lead acetate without quercetin, serum FSH declined (P < 0.05) ~31 to 33% by days 15 and 36, whereas in those given quercetin, FSH did not vary, but LH declined (P < 0.05) ~-29-32%, estrogen ~-35-39% and progesterone 46-47% In ovarian tissue, lead was 78% higher in rats given only lead and 60% higher in those given quercetin (P < 0.05), SOD declined ~-55% and ~-34% whereas MDA increased ~52% and 36%, respectively. Our results suggest that gavage of quercetin could ameliorate ovarian and or hypothamalic chronic lead acetate toxicity in rats.
Keyword: - quercetin, lead, hormones, MDA, SOD