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OJB©
Online Journal of Bioinformatics©
Volume
6 (2) :113-120, 2005
DNA microarray model for
computation of absolute gene expression level
Xu, M
gene21st,
ABSTRACT
Xu M, DNA microarray
model for computation of absolute gene expression level, Online J Bioinformatics 6 (2) : 113-120,
2005. DNA
microarray technology allows massive hybridization of
thousands of genes to generate high through-put DNA hybridization data. The
data is compared to obtain differential gene expression and is input into
clustering program to find co-expressed or co-regulated genes. A drawback is
that the DNA microarray hybridization data does not
directly represent gene expression levels. Transcriptional gene expression
profiling studies only define gene expression levels and changes, and there is
a gap between microarray data and gene expression
levels. A method to acquire the gene expression level of each individual gene
using a higher dimensional DNA microarray data model
which allows the gene expression profiling on the basis of gene expression
levels instead of raw data, is described.
Key-Words:
gene expression, expression levels, DNA model.