©1996-2018.  All Rights Reserved. Online Journal of Veterinary Research. You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors.


Online Journal of Veterinary Research©


Volume 1: 29-34, 2002. Redacted 2018.

Oral acute toxicity of glyphosate in Wistar rats


Dallegrave Ea,  DiGiorgio MFaDalsenter PR,b Langeloh Aa


aDepartment of Pharmacology, Instituto de Ciências Básicas da Sáude, Universidade Federal do Rio Grande do Sul, Porto Alegre/RS, Brazil. bDepartment of Pharmacology, Instituto de Ciências Biológicas, Centro Politécnico, Universidade Federal do Paraná, Curitiba/PR, Brazil. Address for correspondence:Eliane Dallegrave, Mestre em Ciências Veterinárias, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul Rua Sarmento Leite / 500, sala 202, 90046-900 - Porto Alegre/RS. Brasil. Email: elianed@vortex.ufrgs.br




Dallegrave E, Mantese FD, Dalsenter PR, Langeloh A., Oral acute toxicity of glyphosate in Wistar rats, Onl J Vet Res., 1:29-34, 2002. The acute toxicity of glyphosate (N-phosphonomethylglycine with the surfactant polyoxyethyleneamine:Roundup®) was determined 2, 4, 6, 8, 10, 12 and 24 hours after oral administration of 1, 2, 3 or 4g/kg to Wistar rats. Each animal was observed for immediate toxicity up to 12h and for death up to 24h. Signs of toxicity included salivation, diarrhea, gasping, blood-stained nose discharges and seizures. Post mortem examination showed lung hyperemia and liver congestion. The oral acute LD50was found to be 31g/kg (95%confidence limits = 1.81 – 2.95) in Wistar rats, a value 54% lower than that reported in the literature (> 5g/kg).


KEYWORDS: Glyphosate; N-phosphonomethylglycine; polyoxyethyleneamine; DL50; rats; Acute toxicity; Roundup®.