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Online Journal of Veterinary Research©
Volume 1: 29-34, 2002. Redacted 2018.
Oral acute toxicity of glyphosate in Wistar rats
Dallegrave Ea, DiGiorgio MFa, Dalsenter PR,b Langeloh Aa
aDepartment of Pharmacology, Instituto de Ciências Básicas da Sáude, Universidade Federal do Rio Grande do Sul, Porto Alegre/RS, Brazil. bDepartment of Pharmacology, Instituto de Ciências Biológicas, Centro Politécnico, Universidade Federal do Paraná, Curitiba/PR, Brazil. Address for correspondence:Eliane Dallegrave, Mestre em Ciências Veterinárias, Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul Rua Sarmento Leite / 500, sala 202, 90046-900 - Porto Alegre/RS. Brasil. Email: email@example.com
Dallegrave E, Mantese FD, Dalsenter PR, Langeloh A., Oral acute toxicity of glyphosate in Wistar rats, Onl J Vet Res., 1:29-34, 2002. The acute toxicity of glyphosate (N-phosphonomethylglycine with the surfactant polyoxyethyleneamine:Roundup®) was determined 2, 4, 6, 8, 10, 12 and 24 hours after oral administration of 1, 2, 3 or 4g/kg to Wistar rats. Each animal was observed for immediate toxicity up to 12h and for death up to 24h. Signs of toxicity included salivation, diarrhea, gasping, blood-stained nose discharges and seizures. Post mortem examination showed lung hyperemia and liver congestion. The oral acute LD50was found to be 31g/kg (95%confidence limits = 1.81 – 2.95) in Wistar rats, a value 54% lower than that reported in the literature (> 5g/kg).
KEYWORDS: Glyphosate; N-phosphonomethylglycine; polyoxyethyleneamine; DL50; rats; Acute toxicity; Roundup®.
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